Synthetic Cannabinoids in Drug Discovery: Design, Synthesis and Evaluation of Modified Coumarins as CB Receptor Ligands (Beitrage Zur Organischen Synthese #88) (Paperback)

Synthetic Cannabinoids in Drug Discovery: Design, Synthesis and Evaluation of Modified Coumarins as CB Receptor Ligands (Beitrage Zur Organischen Synthese #88) By Florian Mohr Cover Image

Synthetic Cannabinoids in Drug Discovery: Design, Synthesis and Evaluation of Modified Coumarins as CB Receptor Ligands (Beitrage Zur Organischen Synthese #88) (Paperback)

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The endocannabinoid system represents a highly complex lipid-based (neuro-) transmitter system and can be found in nearly all animals. Since the discovery of the two main cannabinoid receptors CB1 and CB2 in the early '90, intensive research reviled a substantial influence of this system on many physiological and pathophysiological processes. Direct and selective targeting of the system bears a huge potential for the development of novel therapeutic approaches, especially for the treatment of chronical pain, inflammation or other neurological disorders. Therefore, the endocannabinoid system is a promising target in drug development. In the presented thesis, the design, syntheses and pharmacologic evaluation of substituted coumarins as potential new drug candidates as selective synthetic cannabinoids were investigated. In a combinatorial synthetic approach, several new libraries of new ligands were synthesised and subsequently pharmacological tested. Additionally, in a second project, novel reversible monoacylglycerol lipase (MAGL) inhibitors have been synthesized and pharmacologically evaluated. Thereby, several important structure-activity relationships for high potency or selectivity were found. Nearly all potencies of the developed inhibitors were determined in the nanomolar regions.
Product Details ISBN: 9783832551032
ISBN-10: 3832551034
Publisher: Logos Verlag Berlin
Publication Date: May 26th, 2020
Pages: 354
Language: English
Series: Beitrage Zur Organischen Synthese